Simple Summary A key molecule, EGFRvIII has been shown to provide several growth
advantages for brain tumors. However, we have found a new mechanism in which the
EGFRvIII provides increased survival to brain cancer cells when under sub-optimal
conditions. Specifically, we have found that the EGFRvIII drives the expression of a molecule
called Reticulocalbin 1 (RCN1) and that RCN1 blocks cell stress and cell death, thereby
allowing cells to survive and proliferate. Importantly, these findings will allow for the …

Reticulocalbin 1 (RCN1) is an endoplasmic reticulum (ER)-residing protein, involved in
promoting cell survival during pathophysiological conditions that lead to ER stress.
However, the key upstream receptor tyrosine kinase that regulates RCN1 expression and its
potential role in cell survival in the glioblastoma setting have not been determined. Here, we
demonstrate that RCN1 expression significantly correlates with poor glioblastoma patient
survival. We also demonstrate that glioblastoma cells with expression of EGFRvIII receptor …